This is my current setup, covering 22 to 450mm in 24x36mm terms. Only my newly acquired FA100mm Makro is missing. I did this shot when I compared my K5 to the Canon 5D Mark I, realizing that a comparable setup from Canon would be twice as heavy and that extra stop in DOF is nothing I need.
Currently I am tempted by microfourthirds, since this setup still requires an extra bag and is too big for business trips. Hope the new K-01 from Pentax will solve this issue